If you’re interested in using food to lower your risk of cancer, remember to eat lots of onions. Research shows that people with the highest consumption of onions as well as other allium vegetables have a lower risk of several types of cancer, including:
- Liver, colon and renal cell (kidney).
- Esophageal and laryngeal.
- Prostate and colorectal.
- Ovarian and endometrial.
Onions contain several anti-cancer compounds, including quercetin, anthocyanins, organosulfur compounds such as diallyl disulfide (DDS), S-allylcysteine (SAC) and S-methylcysteine (SMC) and onionin A (ONA).
Onion Compound Suppresses Ovarian Cancer
Starting with the latter, ONA was recently found to offer protection against epithelial ovarian cancer (EOC), the most common type of ovarian cancer.
ONA, it turns out, slowed growth of EOC. The compound also inhibited other cancerous activities, and enhanced the effects of anti-cancer drugs. Mice fed ONA also lived longer.
According to the authors:
“We found that ONA reduced the extent of ovarian cancer cell proliferation induced by co-culture with human macrophages. In addition, we found that ONA directly suppressed cancer cell proliferation.Thus, ONA is considered useful for the additional treatment of patients with ovarian cancer owing to its suppression of the pro-tumor activation of tumor-associated macrophages and direct cytotoxicity against cancer cells.”
The Stronger an Onion’s Flavor, the More Effective Its Anti-Cancer Effects
Previous research has revealed that the stronger the flavor of the onion, the better its cancer-fighting potential. A 2004 study, in which food scientists analyzed 10 different varieties of onion, the following were found to be particularly effective against liver and colon cancer:
- Liver cancer: shallots, Western yellow onion and pungent yellow onion.
- Colon cancer: pungent yellow onion, Western yellow onion.
- Northern red onions were also found to be high in anti-cancer chemicals, just not quite as potent as the others listed.
- Mild-flavored onions, such as Empire Sweet, Western white, Peruvian sweet and Vidalia had the lowest antioxidant activity, making them less potent in terms of anti-cancer benefits.
Onions are one of the richest sources of flavonoids in the human diet, and flavonoid consumption has been associated with a reduced risk of cancer, heart disease and diabetes. Flavonoids are not only anti-cancer but also are known to be anti-bacterial, anti-viral, anti-allergenic and anti-inflammatory.
Our study of 10 onion varieties and shallots clearly shows that onions and shallots have potent antioxidant and antiproliferation activities and that the more total phenolic and flavonoid content an onion has, the stronger its antioxidant activity and protective effect.
Quercetin — Another Potent Anti-Cancer Compound
Quercetin, another anti-cancer compound found in onions, has been shown to decrease cancer tumor initiation and inhibit the proliferation of cultured ovarian, breast and colon cancer cells. It’s also associated with a decreased risk for brain cancer, and a lower risk of lung cancer if you’re a smoker.
Quercetin has also been shown to help lower blood pressure in hypertensive patients,and helps prevent histamine release, making quercetin-rich foods such as onions natural antihistamines.
Quercetin is available in supplement form, but getting this flavonoid naturally from onions makes more sense for a couple of reasons:
- One animal study found that animals received greater protection against oxidative stress when they consumed yellow onion in their diet, as opposed to consuming quercetin extracts.
- Quercetin is not degraded by low-heat cooking, such as simmering, making onion soup an easy-to-make super food.
Other Beneficial Compounds Found in Onions
The organosulfur compounds DDS, SAC and SMC have also been found to inhibit colon and kidney cancer, in part by inducing cancer cell apoptosis (cell death), but also by inhibiting gene transcription and protecting against ultraviolet-induced immuno suppression.
Onions are also a good source of:
- Fiber, which can help lower your cancer risk, especially colon cancer.
- Vitamin C.
- Anthocyanins (red, purple and blue plant pigments found in red onions). Research has linked anthocyanins to a reduced risk for a number of diseases, including cancer, cardiovascular disease and neurological dysfunction and decline.
They also help prevent obesity and diabetes, in part by inhibiting certain enzymes in your digestive tract, and by supporting healthy blood sugar control. They have potent anti-inflammatory effects, which helps explain their protective effects against chronic disease
The Many Health Benefits of Onions
While onions are gaining a reputation for their anti-cancer properties, the more we learn about onions, the more it becomes clear they offer whole body benefits.
That is the beauty of eating whole foods, after all, because they typically contain many beneficial phyto chemicals that enhance your health in numerous synergistic ways.
As for onions, research has shown that including onions in your diet may offer the following benefits:
- Prevent inflammatory processes associated with asthma.
- Reduce symptoms associated with diabetes.
- Lower levels of cholesterol and triglycerides.
- Reduce symptoms associated with osteoporosis and improve bone health.
- Maintain gastrointestinal health by sustaining beneficial bacteria.
- Diminish replication of HIV.
- Reduce risk of neurodegenerative disorders.
- Lower your risk of cataract formation.
- Antimicrobial properties that may help reduce the rate of food-borne illness.
- Improvement of intestinal flora, improved absorption of calcium and magnesium due to the fructans they contain.
- Antibacterial, antifungal, antioxidant and anti-inflammatory properties.
Improved heart health. The sulfur compounds have anti-clotting properties and help improve blood lipid profiles.The allium and allyl disulphide in onions also help decrease blood vessel stiffness by enhancing nitric oxide release.
This may reduce blood pressure, inhibit platelet clot formation, and help decrease the risk of coronary artery disease, peripheral vascular diseases, and stroke.
Tips for Storing and Preparing Onions
If learning about their health benefits has inspired you to eat more onions, you’re in luck as they are incredibly versatile and come in a variety of colors and flavors. Keep in mind that the antioxidants tend to be most concentrated in the OUTER layers of the onion, so avoid overpeeling.
Ideally, peel off only the outermost paper-like layer. Peeling too many layers can reduce the onion’s quercetin and anthocyanin content by as much as 20 percent and 75 percent respectively.
One piece of good news is that quercetin does not degrade when cooked over low heat, so when you’re making soup, for example, it simply transfers into the broth.
As for storing your onions, do NOT keep them in plastic. Whole, dry bulbs should be stored in a cool, dry and dark place with plenty of air movement to maximize shelf life.
To extend shelf life of sweet or mild onion varieties, which have a higher water content, you can store the whole bulbs in the fridge. Once an onion has been cut or peeled, it can be refrigerated in a sealed container for about a week before it starts going bad. Leaving a cut onion in room temperature can significantly reduce its antibacterial properties.